Hyperinsulinism is the presence of excess insulin in the body resulting in hypoglycemia. Insulinomas are rare pancreatic tumors that secrete excess insulin, causing low blood sugar and symptoms such as confusion, dizziness, headache, visual disturbances, sweating, tremors, and palpitations.

What is a clinical study?

Clinical research determines whether a drug candidate or device is safe and effective. Participation is voluntary and participants may leave at any time.

What is an expanded access program?

Expanded access, sometimes called compassionate use, allows patients with serious or life-threatening conditions to receive investigational medical products outside clinical studies when no satisfactory alternatives exist.

Will my results contribute to the ersodetug study?

Yes, if eligibility criteria are met and data are provided, results may be included in the research program.

How long is the research program?

Participants attend weekly visits for 8 weeks and may continue in an extension phase for up to 3 years.

Can I stop participation early?

Yes, participation is voluntary and you may withdraw at any time without providing a reason.

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Is your insulinoma causing unpredictably low blood sugar?

Learn about the upLIFT Clinical Program for patients with low blood sugar (hypoglycemia) due to insulinomas

What are insulinomas?

Insulinomas are a rare tumor type that affect cells in the pancreas, which secrete insulin. Insulin is a hormone that helps regulate blood sugar (glucose) after a meal by allowing it to move from the bloodstream into muscles, fat, and the liver, where it is used or stored.

A healthy pancreas secretes the right amount of insulin to keep blood sugar levels stable. But in a pancreas with insulinomas, the tumor cells produce excess insulin, causing too much glucose to be taken from the blood and blood sugar levels to drop. This leads to frequent episodes of low blood sugar called hypoglycemia. Even small insulinomas can lead to hypoglycemia.

Most insulinomas are benign, which means they are not cancerous. Approximately 10% of cases are malignant.

Illustration showing how insulinomas cause excess insulin release from the pancreas, leading to increased glucose uptake into cells.

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Symptoms

People with insulinomas may experience:

Symptoms that are brain-related, which show that the brain isn’t getting enough glucose. These include confusion, visual disturbances, seizures, or coma
Symptoms caused by the body responding to low blood sugar, like sweating, tremors, or palpitations

Did you know? Repeated episodes of hypoglycemia may also make it harder to recognize warning signs of low blood sugar, a condition known as hypoglycemia unawareness.

"It happened a couple of times over a few months. I’d be out walking the dog, and I’d suddenly faint and I had never fainted before. I didn’t realize at the time what it was. Then about a month later, it happened again. I hadn’t eaten anything that morning, and that’s when things really started to make sense.”

—Patient living with insulinoma

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Resources

Check out the following websites for more educational information about insulinoma.

Insulinoma Charity UK

Neuroendocrine Cancer Foundation

NANETS (North American Neuroendocrine Tumor Society)

National Comprehensive Cancer Network

National Organization for Rare Disorders

Frequently asked questions

What are insulinomas?

Insulin is a hormone that helps regulate blood sugar (glucose) after a meal by allowing it to move from the bloodstream into muscles, fat, and the liver, where it is used or stored.

A healthy pancreas secretes the right amount of insulin to keep blood sugar levels stable. But in a pancreas with insulinomas, the tumor cells produce excess insulin, causing too much glucose to be taken from the blood and blood sugar levels to drop. This leads to frequent episodes of low blood sugar called hypoglycemia. Even small insulinomas can lead to hypoglycemia.

Are insulinomas considered cancer?

What type of doctor treats insulinomas?

How is hypoglycemia diagnosed in people with insulinomas?

Hypoglycemia is determined by the following 3 factors, often referred to as Whipple's triad:

Patient shows symptoms of hypoglycemia
Blood tests confirm that blood sugar is low
Symptoms go away when blood sugar is raised to normal

Once the doctor diagnoses you with hypoglycemia, they may order additional tests or perform additional procedures (for example, a fasting study) to confirm if it's due to insulinoma.

Is it possible for insulinomas to go undiagnosed due to mild hypoglycemia?

Yes, some people may not know they are living with insulinomas because they aren't experiencing the typical symptoms that indicate hypoglycemia. Even in some cases of severe hypoglycemia, a patient may not know they are experiencing it until they require hospitalization.

Other people may go undiagnosed due to a phenomenon called "hypoglycemia unawareness"—which happens when repeated episodes of hypoglycemia make it harder to recognize the warning signs of low blood sugar.

Are there patient community groups for people living with insulinomas?

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Rezolute is a late‑stage rare disease company working to improve the lives of people with insulinoma. Sign up to receive information on new developments, events, and educational resources.

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